It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body.
Discovery of penicillin
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"It was not easy to convince people of the importance of penicillin in the early days."
Shocking"I have been asked by many people how I came to discover penicillin. The answer is that I did not discover it. I just happened to notice it."
Strange & Unusual"I have always been interested in the effect of one microbe on another."
Strange & Unusual"One sometimes finds what one is not looking for."
Strange & Unusual"If penicillin can cure those that are ill, Spanish sherry can bring the dead back to life."
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